CV 1.131

Samuel A. Hurley, Ph.D.

Magnetic Resonance Imaging and Positron Emission Tomography Physicist

Document Last Updated: Feb 2019

Contact

Mobile Phone: +1 (608) 318-3063

Work Email: shurley[@]wisc.edu

Home Email: samuel.hurley[@]gmail.com

Skype: samuel.hurley

Web: www.paradime.net

NIH Biosketch: NIH CV

Research Positions

Assistant Scientist

July 2018 - Present

Department of Radiology

University of Wisconsin, Madison, WI

Advisors: Prof. Frank Korosec, Prof. Alan McMillan

Research Associate

Jan 2017 - June 2018

Departments of Neuroscience and Radiology

University of Wisconsin, Madison, WI

Advisors: Prof. Luis C. Populin, Dr. Alan McMillan

Research Fellow

Jul 2016 - Present

Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB)

John Radcliffe Hospital

University of Oxford, Oxford, Oxfordshire

Advisor: Professor Karla Miller

MRI Physics Support Scientist

October 2014 - March 2016

Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB)

John Radcliffe Hospital

University of Oxford, Oxford, Oxfordshire

Advisor: Professor Stuart Clare

Wisconsin Distinguished Graduate Fellow

Sept 2013 - Aug 2014

Waisman Laboratory for Brain Imaging and Behavior

University of Wisconsin, Madison, WI

Advisor: Professor Andrew L. Alexander

Research Assistant

May 2008 - Aug 2013

Waisman Laboratory for Brain Imaging and Behavior

University of Wisconsin, Madison, WI

Advisor: Professor Andrew L. Alexander

Undergraduate Assistant

May 2007 - May 2008

Applied Neuro FMRI Lab

University of Wisconsin, Madison, WI

Advisor: Professor M. Elizabeth Meyerand

Industry Positions

MRI Applications Scientist

April 2016 - Jan 2017

Synaptive Medical

Milwaukee, WI, USA

Toronto, ON, Canada

Teaching Experience

University of Oxford Doctoral Training Centre (DTC),

Oxford-Nottingham Biomedical Imaging Course (ONBI)

Michaelmas Term 2014, Trinity Term, 2015, Michaelmas Term 2015

Image Formation, Susceptibility-Based Contrast Lectures

Tutor - MRI Physics MATLAB Tutorial

FMRIB Graduate Programme

Michaelmas Term 2015 - Physics Course Tutor

Education

Doctor of Philosophy (Ph.D.), Medical Physics 2014

University of Wisconsin, Madison, WI

Thesis: Rapid and Accurate Single and Multi-Component Relaxometry Using Steady-State Acquisitions

Academic Advisor: Professor Andrew L. Alexander

Co-Advisors: Professor Aaron S. Field, Dr. Alexey A. Samsonov

Master of Science (M.S.), Medical Physics 2010

University of Wisconsin, Madison, WI

Bachelor of Science (B.S.) Physics 2008

University of Wisconsin, Madison, WI

Skills

Scientific Computing: MATLAB, C, CUDA, Linux/Unix sysadmin (RedHat/CentOS, Debian/Ubuntu, macOS)

Pulse Programming: GE Healthcare EPIC, Siemens IDEA/ICE, Agilent VnmrJ

FAA Private Pilot: Airplane Single Engine Land (ASEL)

Musician: Fringe Field - Bass Guitarist. 2010-2014, 2018-Present. www.fringefield.com

Peer-Reviewed Publications

Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC.  Changes in Endogenous Dopamine Induced by Methylphenidate Predict Functional Connectivity in Nonhuman Primates. J Neurosci. 2019 Feb 20;39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018

Schmid AB, Campbell J, Hurley SA, Jbabdi S, Andersson JL, Jenkinson M, Bangerter NK, Bennett DL, Tracey I, Frost R, Clare S. Feasibility of Diffusion Tensor and Morphologic Imaging of Peripheral Nerves at Ultra-High Field Strength. Invest Radiol. 2018 Dec;53(12):705-713. doi: 10.1097/RLI.0000000000000492

Heath F, Hurley SA, Johansen-Berg H, Sampaio-Baptista C. Advances in noninvasive myelin imaging. Dev Neurobiol. 2017 Oct 30. doi: 10.1002/dneu.22552. [Epub ahead of print] 

Dean DC, Hurley SA, Kecskemeti SR, O'Grady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB. Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease. JAMA Neurol. 2017;74(1):41-49. doi:10.1001/jamaneurol.2016.3232

Wood TC, Simmons C, Hurley SA, Vernon AC, Torres J, Dell’Acqua F, Williams SCR, Cash D. Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model. (2016) PeerJ 4:e2632 https://doi.org/10.7717/peerj.2632

Dean DC III, Sojkova J, Hurley S, Kecskemeti S, Okonkwo O, Bendlin BB, et al.  Alterations of Myelin Content in Parkinson’s Disease: A Cross-Sectional Neuroimaging Study. PLoS ONE 2016;11(10): e0163774. doi:10.1371/journal.pone.0163774

Goskan S, Hartley C, Hurley SA, Winkler AM, Duff EP, Jenkinson M, Rogers R, Clare S, Slater R. Optimal echo time (TE) for functional MRI of the infant brain identified in response to noxious stimulation. MRM 2016 Sept 21. (doi: 10.1002/mrm.26455 Epub ahead of print)

Lewis CM, Hurley SA, Meyerand ME, Koay CG. Data-driven optimized flip angle selection for T1 estimation from spoiled gradient echo acquisitions. MRM 2016;76(3):792-802. doi: 10.1002/mrm.25920. Epub 2015 Sep 12.

Venkateswaran M, Unal O, Hurley S, Samsonov A, Wang P, Fain S, Kurpad K. Modeling Endovascular MRI Coil Coupling with Transmit RF Excitation. IEEE Trans Biomed Eng. 2016 Mar 4. PubMed PMID: 26960218; PubMed Central PMCID: PMC5011021.

Kecskemeti SR, Samsonov AA, Hurley SA, Dean DC, Field AS, Alexander AL. MPnRAGE: A technique to simultaneously acquire hundreds of differently contrasted MPRAGE images with applications to quantitative T1 mapping. MRM 2016;75(3):1040-1053. doi: 10.1002/mrm.25674. Epub 2015 Apr 17.

Emborg ME, Hurley SA, Joers V, Tromp do PM, Swanson CR, Ohshima-Hosoyama S, Bondarenko V, Cummisford K, Sonnemans M, Hermening S, Blits B, Alexander AL. Titer and product affect the distribution of gene expression after intraputaminal convection-enhanced delivery. Stereotact Funct Neurosurg 2014;92(3):182-94. doi: 10.1159/000360584. Epub 2014 Jun 12.

Osting S, Bennett A, Power S, Wackett J, Hurley SA, Alexander AL, Agbandje-Mckena M, Burger C. Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum. Mol Ther Methods Clin Dev 2014;1:4

Liu F, Chaudhary R, Hurley SA, Munoz Del Rio A, Alexander AL, Samsonov A, Block WF, Kijowski R. Rapid multicomponent T2 analysis of the articular cartilage of the human knee joint at 3.0T. J Magn Reson Imaging 2014:39(5):1191-1197

Alexander AL, Hurley SA, Samsonov AA, Adluru N, Hosseinbor AP, Mossahebi P, Tromp DPM, Zakszewski E, Field AS. Characterization of Cerebral White Matter Properties Using Quantitative MRI Stains. Brain Connectivity 2011;1(6):423-466

Hurley SA, Yarnykh VL, Johnson KM, Field AS, Alexander AL, Samsonov AA. Simultaneous Variable Flip Angle-Actual Flip Angle Imaging Method for Improved Accuracy and Precision of Three-Dimensional T1 and B1 Measurements.  MRM 2012;68:54-64

Cheng GK, Hurley SA, Meyerand ME. Extremely efficient and deterministic approach to generating optimal ordering of diffusion MRI measurements. Med Phys 2011;38(8):4795–4801

Yang X, Hong H, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Xiao Y, Yang Y, Zhang Y, Nickles RJ, Cai W, Steeber DA, Gong S. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials 2011;32(17):4151-4160

Yang X, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Matson VZ, Steeber DA, Gong S.  Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging. ACS Nano 2010;4(11):6805-6817

Yang X, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Steeber DA, Gong S. Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging. Biomaterials 2010;31(34):9065-9073

US Patents

US848284 B2. Cheng Guan Koay and Hurley, Samuel A. Method for Determining and Ordering K-Space Views and Diffusion Weighted Directions. Wisconsin Alumni Research Foundation, assignee. 9-July-2013.

Conference Attendance

Annual Meeting of ISMRM

• Jun 2018 - 26th - Paris, France

• April 2017 - 25th - Honolulu, Hawaii, USA

• May 2015 - 23rd - Toronto, Ontario, Canada

• May 2014 - 22nd - Milan, Lombardy, Italy. (UW Vilas Travel Grant awardee)

• May 2012 - 20th - Melbourne, Victoria, Australia. (Student stipend award winner)

• May 2011 - 19th - Montreal, Quebec, Canada. (Student stipend award winner)

• May 2010 - 18th - Stockholm, Sweden

• May 2009 - 17th - Honolulu, Hawai`i, United States of America. (Student stipend award winner)

• May 2008 - 16th - Toronto, Ontario, Canada

Other

• October 2018 - ISMRM Workshop on Machine Learning, Part II. (poster presentation)

• March 2011 - IEEE International Society of Biomedical Imaging (ISBI) - Chicago, IL. (Student stipend award)

• Jan 2011 - National MS Society (NMSS) Repair 2010 Investigator's Meeting - New York, NY

Conference Proceedings - Primary Author

Hurley SA, Johnson JM, McMillan AB. DeepTOPUP: Distortion Correction of Spin Echo EPI from Phase-Reversed Acquisitions using Deep Learning. In: Proceedings of the ISMRM Workshop on Machine Learning Part II, Washington, DC, USA 2018.

Hurley SA, Johnson JM, Bendlin BB, McMillan AB. Quantitative Synthetic T1 Mapping of the Brain from Structural Imaging using Deep Learning (Traditional Poster, Abstract #2772) In: Proceedings of the 27th Annual Meeting of ISMRM, Paris, France 2018

Hurley SA, McMillan AB. A Method to Quantitatively Assess and Compare Diffusion MRI Protocols between MR Systems (Traditional Poster, Abstract #1665) In: Proceedings of the 27th Annual Meeting of ISMRM, Paris, France 2018

Hurley SA, Alexander AL. Assessment of mcDESPOT Precision Using Constrained Estimation (Traditional Poster, Abstract #3144) In: Proceedings of the 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014

Hurley SA, Mossahebi P, Johnson KM, Samsonov AA. Simultaneous Mapping of B1 and Flip Angle by Combined Bloch-Siegert, Actual Flip-angle Imaging (BS-AFI) (Oral Presentation, Abstract #0050) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Victoria, Australia 2012

Hurley SA, Tromp DPM, Emborg ME, Ohshima-Hosoyama S, Brady M, Raghavan R, Kubota K, Alexander AL. MR Monitoring of Non Contrast-enhanced brain infusion with MRI T1 Mapping (Traditional Poster, Abstract #0048) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Victoria, Australia 2012 *Interventional Study Group Top 10 Poster Award.

Hurley SA, Yarnykh VL, Samsonov AA. Spoiling properties of the VAFI method for fast simultaneous T1 and B1 mapping from actual flip-angle imaging (AFI) and variable flip-angle (VFA) data. (E-Poster, Abstract #4488) In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2011

Hurley SA*, Mossahebi P*, Samsonov AA, Alexander AL, Deoni SC, Fisher R, Duncan ID, Field AS. Multicomponent Relaxometry (mcDESPOT) in the Shaking Pup Model of Dysmyelination. (E-Poster, Abstract #0088)  In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden 2010

Hurley SA, Samsonov AA. Accurate and Efficient Mapping of Flip Angle and T1 using Simultaneous Actual Flip Angle - Variable Flip Angle Imaging. (E-Poster, Abstract #4480) In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, HI, USA 2009

*Equal contribution among starred authors.

Conference Proceedings - Contributing Author

Clarke C, Kitzbichler M, Barker G, Correia M, Dowell N, Hurley SA, Mclean J, Wood TC, NIMA Consortium, Cercignani M, Bullmore E, Harrison N. BIOmarkers of DEPression (BIODEP) study: Raised peripheral inflammation associated with changes in striatal microstructure (E-Poster, Abstract #3661) In: 27th Annual Meeting of ISMRM, Paris, France 2018

Feng Q, Hurley SA, Pallebage-Gamarallage M, Ansorge O, Turner M, Menke R, Foxley S, Miller KL. Correction of Fixation Effects in Post-Mortem T2 Measurements Using a Kinetic Tensor Model (E-Poster, Abstract #3728) In: 25th Annual Meeting of ISMRM, Honolulu, HI, USA, 2017

Metere R, Hurley SA, Pampel A, Miller KL, Möller H. A Singular Value Decomposition Approach to Quantitative Magnetization Transfer (Traditional Poster, Abstract #1969) In: 25th Annual Meeting of ISMRM, Honolulu, HI, USA, 2017

Wood TC, Simmons C, Torres J, Dell'Acqua F, Vernon A, Hurley SA, Williams S, Cash D. Whole-Brain Ex-Vivo Imaging of Demyelination in the Cuprizone Mouse with McDESPOT and DTI (Traditional Poster, Abstract #1317) In: 24th Annual Meeting of ISMRM, Republic of Singapore, 2016

Alexander D, Ghosh A, Hurley SA, Sotiropoulos S. Image Quality Transfer Benefits Tractography of Low-Resolution Data (Oral, Abstract #0120) In: 24th Annual Meeting of ISMRM, Republic of Singapore, 2016

Bouyagoub S, Dowell N, Hurley SA, Wood TC, Cercignani M. Overestimation of CSF Fraction in NODDI: Possible Correction Techniques and the Effect on Neurite Density and Orientation Dispersion Measures (E-Poster, Abstract #0007) In: 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014

Wood TC, Hurley SA, Barker GJ, Williams SCR. An SSFP Signal Equation with Finite RF Pulses and Exchanging Water Pools (Traditional Poster, Abstract #1464) In: 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014

Chaudhary R, Liu F, Sritanyaratana N, Kaiser JM, Hurley SA, Block WF, Kijowski R. Sensitivity of Multicomponent Driven Equilibrium Single Observation of T1 and T2 (mcDESPOT) to Magic Angle Effects in Bovine Articular Cartilage at 3.0T (Oral Presentation, Abstract #0149) In: Proceedings of the 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014

McLellan GL, Hurley SA, Mossahebi P, Ellinwood NM, Field AS. Quantitative MRI-derived optic nerve microstructural features in a feline glaucoma model. ARVO-ISIE Imaging Conference, Orlando, Florida, May 2014

Grabow BP, Kubota K, Raghavan R, Brady M, Ross C, Hurley SA, Brodsky EK. Real-Time Monitoring For Systematic Investigation Of Catheter Design And Infusion Protocol Effect On CED Performance. In: 17th International Congress Of Parkinson's Disease And Movement Disorders, Volume 28, Sydney, Australia, 16-20 June 2013.

Grabow BP, Raghavan R, Brady M, Kubota K, Ross C, Hurley SA, Brodsky EK, Raschke J, Alexander AL, Block WF. Real-Time Monitoring For Systematic Investigation Of Catheter Design And Infusion Protocol Effect On CED Performance. In: 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013.

Kecskemeti S, Adluru N, Hurley S, Alexander AL. Multi-spectral T1 Weighted Imaging and T1 Quantification using 3D Radial k-space Trajectory (Traditional Poster, Abstract #0452) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013

Liu F, Chaudhary R, Hurley SA, Samsonov AA, Alexander AL, Deoni SCL, Block WF, Kijowski R. Multi-Component T2 Analysis of Cartilage Degradation Model Using mcDESPOT at 3.0T (Traditional Poster, Abstract #1655) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013

Liu F, Hurley SA, Samsonov AA, Alexander AL, Deoni SCL, Block WF, Kijowski R. Multi-Component T2 Analysis of Articular Cartilage with Synovial Fluid Partial Volume Correction  using mcDESPOT at 3.0T (Oral Presentation, Abstract #0636) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013

Wood TC, Hurley SA, Vernon A, Williams SCR. High Resolution Imaging of Rodent Brains at 7T. (Traditional Poster, Abstract #2465) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013

Ollinger JM, Hurley SA, Alexander AL, Riedy G. A Constrained Estimator of Myelin Water Fraction from Steady-State Data (Traditional Poster, Abstract #4210) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013

Venkateswaran M, Hurley SA, Samsonov AA, Wang P, Unal O, Kurpad KN. An Accurate Electromagnetic Field Model for Optimization and Selection of Intravascular Multimode Coil Geometry (Traditional Poster, Abstract #4317) In: 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013

Hutchinson, E., Elangbam, N., Hurley, SA., Alexander, A., Rutecki, P., Sutula, T. Quantitative Manganese-enhanced MRI detection of differences between kindling-susceptible and kindling-resistant strains of rats. In: Society for Neuroscience, New Orleans, LA, USA October 2012.

Grabow BP, Block WF, Hurley SA, Sillay KA, Brodsky EK. Accessible Animal Models for Interventional Neurosurgery Training and Research (Poster Presentation, Abstract #112) In: 9th International Interventional MRI Symposium, Boston, MA, USA 2012.

Venkateswaran M, Kurpad KN, Hurley SA, Wang P, Unal O. Endovascular Multimode Coil Characterization Using B1 Field Mapping (Poster Presentation, Abstract #087) In: 9th International Interventional MRI Symposium, Boston, MA, USA 2012.

Liu F, Hurley SA, Sritanyaratana N, Block WF, Kijowski R. Multi-Exponential T2 Mapping of Human Patellar Cartilage Using mcDESPOT (Oral Presentation, Abstract #4365) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Victoria, Australia 2012

Tromp DPM, Emborg ME, Hurley SA, Adluru N, Brady ML, Raghavan R, Kubota K, Alexander AL. Retrospective R1 Atlas Mapping of Brain Infusions (Traditional Poster, Abstract #3830) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Victoria, Australia 2012

Brodsky EK, Block WF, Alexander AL, Grabow BP, Hurley SA, Ross CD, Sillay KA. Intraoperative Targeting, Trajectory Planning, Device Insertion and Infusion Monitoring with Real-Time MRI (Oral Presentation) In: International MRA Club 23rd Annual Conference, Bannf, Alberta, Canada. September 2011.

Velikina JV, Hurley SA, Alexander AL, Samsonov AA. Accelerating Multi-Component Relaxometry in Steady State with an Application of Constrained Reconstruction in Parametric Dimension. (Abstract #2740) In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2011

Sritanyaratana N, Samsonov AA, Hurley SA, Johnson KM, Mossahebi P, Block WF, Kijowski R.Quantitative Magnetization Transfer of Entire Human Patellofemoral Joint in 30 Minutes. (E-Poster, Abstract #4318) In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2011

Hosseinbor AP, Duncan ID, Alexander AL, Samsonov AA, Wu Y-C, Hurley SA, Fisher RA, Field AS. Hybrid Diffusion Imaging in a Spinal Cord Model of Dysmyelination. (Traditional Poster, Abstract #2135) In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden 2010

Lopas LA, Moirano JM, Kurpad KN, Hurley SA, Converse AK. Design, Construction, and Testing of RF Coil and Animal Body Holder for Simultaneous PET/MRI Imaging of Rat Brain. (Traditional Poster) BrainPET (2009)

Projects

Quantitative MRI Analysis Package - Samsonov AA, Mossahebi P, Hurley SA.  www.qmri.net/qmap

A collection of quantitative MRI analysis software written in Matlab. This includes mathematical models of MRI sequences for measurement of quantitative parameters including T1, T2, bound pool fraction, and exchange rates. 

ISMRM Challenge - Organizing Committee Member. www.ismrm.org/challenge

ISMRM Challenge is an initiative to foster impactful innovation in MRI applications and methodology through a series of year-around competitions. It is based on the premise of individuals and teams submitting reconstruction codes, which are tested and scored against a series of test cases in an automated fashion.

• 2012-2013 Challenge: Robust Fat/Water Separation

• 2013-2014 Challenge: Sub-Nyquist Reconstruction of Dynamic Imaging

• 2015-2016 Challenge: Radiofrequency (RF) Pulse Design

Associations

• ISMRM (International Society of Magnetic Resonance in Medicine) - Trainee Member (2008-Present)

• Kappa Eta Kappa (Professional Electrical Engineering Fraternity) - National President (Feb 2011-Feb 2012; Feb 2013-Mar 2015); Alumni Director (2013-2014)

• Society of Physics Students - Chapter Vice President (2008-2009)