Samuel A. Hurley, Ph.D. Document Last Updated: Nov 2021 Contact Phone: +1 (608) 318-3063 Skype: samuel.hurley Current Research Positions Scientist I Past Research Positions Research Associate Research Fellow MRI Physics Support Scientist Wisconsin
Distinguished Graduate Fellow Research Assistant
Undergraduate Assistant Industry Positions MRI Applications Scientist Teaching Experience University of Oxford Doctoral Training
Centre (DTC), Michaelmas Term
2014, Trinity Term 2015, Michaelmas Term 2015 FMRIB Graduate Programme Michaelmas Term 2015 - Physics Course Tutor Education Doctor of
Philosophy (Ph.D.), Medical Physics 2014 Master of
Science (M.S.), Medical Physics 2010 Bachelor of
Science (B.S.) Physics 2008 Skills Scientific
Computing: MATLAB, C,
CUDA, Python, Keras/Tensorflow, Linux/Unix Sysadmin Peer-Reviewed Publications Kitzbichler MG, Aruldass AR, Barker GJ, Wood TC, Dowell NG, Hurley SA, McLean J, Correia M, Clarke C, Pointon L, Cavanagh J, Cowen P, Pariante C, Cercignani M. Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA) Consortium, Edward T. Bullmore ET, Harrison NA. Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks. Molecular Psychiatry 2021 https://doi.org/10.1038/s41380-021-01272-1 Tendler BC, Feng Q, Foxley S, Pallebage-Gamarallage M, Menke RAL, Ansorge O, Hurley SA, Miller KL. A method to remove the influence of fixative concentration on postmortem T2 maps using a kinetic tensor model. HBM 2021 https://doi.org/10.1002/hbm.25661 Colbert MK, Ho LC, van der Merwe Y, Yang X, McLellan GJ, Hurley SA, Field AS, Yun H, Du Y, Conner IP, Parra C, Faiq MA, Fingert JH, Wollstein G, Schuman JS, Chan K. Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models. IOVS 2021 62 (10), 21-21 Juryńczyk M, Klimiec-Moskal E, Kong Y, Hurley S, Messina S, Yeo T, Jenkinson M, Leite MI, Palace J. Elucidating distinct clinico-radiologic signatures in the borderland between neuromyelitis optica and multiple sclerosis. J Neurol 2021. https://doi.org/10.1007/s00415-021-10619-1 Spangler-Bickell MG, Hurley SA, Pirasteh A, Perlman S, Deller T, McMillan A. Clinical Evaluation of Data-Driven Motion Corrected Reconstruction for PET Brain Imaging. Journal of Nuclear Medicine 2021 62 (supplement 1) 59 Spangler‐Bickell MG, Hurley SA, Deller TW, Jansen F, Bettinardi V, Carlson M, Zeineh M, Zaharchuk G and McMillan AB. Optimizing the frame duration for data‐driven rigid motion estimation in brain PET imaging. Medical Physics 2021 ePub https://doi.org/10.1002/mp.14889 Fowler AM , Kumar M, Bancroft LH, Salem K, Johnson JM, Karow J, Perlman SB, Bradshaw TJ, Hurley SA, McMillan AB, Strigel RM. Measuring Glucose Uptake in Primary Invasive Breast Cancer Using Simultaneous Time-of-Flight Breast PET/MRI: A Method Comparison Study with Prone PET/CT. Radiology: Imaging Cancer 2021 3(1) e200091 Alvarez I, Hurley SA, AJ Parker, H Bridge. Human primary visual cortex shows larger population receptive fields for binocular disparity-defined stimuli. bioRxiv 2021 https://doi.org/10.1101/2021.03.10.434843 Deller TW, Mathew NK, Hurley SA, Bobb CM, McMillan AB. PET Image Quality Improvement for Simultaneous PET/MRI with a Lightweight MRI Surface Coil. Radiology 2021 298 (1):166-172 Collick BD, Behzadnezhad B, Hurley SA, Mathew NK, Behdad N, Lindsay SA, Robb F, Stormont RS, McMillan AB. Rapid development of application-specific flexible MRI receive coils. Phys Med Bio 2020 65 19NT01 Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC. Changes in Endogenous Dopamine Induced by Methylphenidate Predict Functional Connectivity in Nonhuman Primates. J Neurosci. 2019 Feb 20;39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018 Schmid AB, Campbell J, Hurley SA, Jbabdi S, Andersson JL, Jenkinson M, Bangerter NK, Bennett DL, Tracey I, Frost R, Clare S. Feasibility of Diffusion Tensor and Morphologic Imaging of Peripheral Nerves at Ultra-High Field Strength. Invest Radiol. 2018 Dec;53(12):705-713. doi: 10.1097/RLI.0000000000000492 Heath F, Hurley SA, Johansen-Berg H, Sampaio-Baptista C. Advances in noninvasive myelin imaging. Dev Neurobiol. 2017 Oct 30. doi: 10.1002/dneu.22552. [Epub ahead of print] Dean DC, Hurley SA, Kecskemeti SR, O'Grady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB. Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease. JAMA Neurol. 2017;74(1):41-49. doi:10.1001/jamaneurol.2016.3232 Wood TC, Simmons C, Hurley SA, Vernon AC, Torres J, Dell’Acqua F, Williams SCR, Cash D. Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model. (2016) PeerJ 4:e2632 https://doi.org/10.7717/peerj.2632 Dean DC III, Sojkova J, Hurley S, Kecskemeti S, Okonkwo O, Bendlin BB, et al. Alterations of Myelin Content in Parkinson’s Disease: A Cross-Sectional Neuroimaging Study. PLoS ONE 2016;11(10): e0163774. doi:10.1371/journal.pone.0163774 Grissom WA, Setsompop K, Hurley SA, Tsao J, Velikina JV, Samsonov AA. Advancing RF pulse design using an open-competition format: Report from the 2015 ISMRM challenge. Magn Reson Med. 2017 Oct;78(4):1352-1361. doi: 10.1002/mrm.26512 Goskan S, Hartley C, Hurley SA, Winkler AM, Duff EP, Jenkinson M, Rogers R, Clare S, Slater R. Optimal echo time (TE) for functional MRI of the infant brain identified in response to noxious stimulation. MRM 2016 Sept 21. (doi: 10.1002/mrm.26455 Epub ahead of print) Lewis CM, Hurley SA, Meyerand ME, Koay CG. Data-driven optimized flip angle selection for T1 estimation from spoiled gradient echo acquisitions. MRM 2016;76(3):792-802. doi: 10.1002/mrm.25920. Epub 2015 Sep 12. Venkateswaran M, Unal O, Hurley S, Samsonov A, Wang P, Fain S, Kurpad K. Modeling Endovascular MRI Coil Coupling with Transmit RF Excitation. IEEE Trans Biomed Eng. 2016 Mar 4. PubMed PMID: 26960218; PubMed Central PMCID: PMC5011021. Kecskemeti SR, Samsonov AA, Hurley SA, Dean DC, Field AS, Alexander AL. MPnRAGE: A technique to simultaneously acquire hundreds of differently contrasted MPRAGE images with applications to quantitative T1 mapping. MRM 2016;75(3):1040-1053. doi: 10.1002/mrm.25674. Epub 2015 Apr 17. Emborg ME, Hurley SA, Joers V, Tromp do PM, Swanson CR, Ohshima-Hosoyama S, Bondarenko V, Cummisford K, Sonnemans M, Hermening S, Blits B, Alexander AL. Titer and product affect the distribution of gene expression after intraputaminal convection-enhanced delivery. Stereotact Funct Neurosurg 2014;92(3):182-94. doi: 10.1159/000360584. Epub 2014 Jun 12. Osting S, Bennett A, Power S, Wackett J, Hurley SA, Alexander AL, Agbandje-Mckena M, Burger C. Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum. Mol Ther Methods Clin Dev 2014;1:4 Liu F, Chaudhary R, Hurley SA, Munoz Del Rio A, Alexander AL, Samsonov A, Block WF, Kijowski R. Rapid multicomponent T2 analysis of the articular cartilage of the human knee joint at 3.0T. J Magn Reson Imaging 2014:39(5):1191-1197 Alexander AL, Hurley SA, Samsonov AA, Adluru N, Hosseinbor AP, Mossahebi P, Tromp DPM, Zakszewski E, Field AS. Characterization of Cerebral White Matter Properties Using Quantitative MRI Stains. Brain Connectivity 2011;1(6):423-466 Hurley SA, Yarnykh VL, Johnson KM, Field AS, Alexander AL, Samsonov AA. Simultaneous Variable Flip Angle-Actual Flip Angle Imaging Method for Improved Accuracy and Precision of Three-Dimensional T1 and B1 Measurements. MRM 2012;68:54-64 Cheng GK, Hurley SA, Meyerand ME. Extremely efficient and deterministic approach to generating optimal ordering of diffusion MRI measurements. Med Phys 2011;38(8):4795–4801 Yang X, Hong H, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Xiao Y, Yang Y, Zhang Y, Nickles RJ, Cai W, Steeber DA, Gong S. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials 2011;32(17):4151-4160 Yang X, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Matson VZ, Steeber DA, Gong S. Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anticancer Drug Delivery and Ultrasensitive MR Imaging. ACS Nano 2010;4(11):6805-6817 Yang X, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Steeber DA, Gong S. Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging. Biomaterials 2010;31(34):9065-9073 US Patents US848284 B2. Cheng Guan Koay and Hurley, Samuel A. Method for Determining and Ordering K-Space Views and Diffusion Weighted Directions. Wisconsin Alumni Research Foundation, assignee. 9-July-2013. Conference Proceedings - Primary Author Hurley SA, Johnson JM, McMillan AB. DeepTOPUP: Distortion Correction of Spin Echo EPI from Phase-Reversed Acquisitions using Deep Learning. In: Proceedings of the ISMRM Workshop on Machine Learning Part II, Washington, DC, USA 2018. Hurley SA, Johnson JM, Bendlin BB, McMillan AB. Quantitative Synthetic T1 Mapping of the Brain from Structural Imaging using Deep Learning (Traditional Poster, Abstract #2772) In: Proceedings of the 27th Annual Meeting of ISMRM, Paris, France 2018 Hurley SA, McMillan AB. A Method to Quantitatively Assess and Compare Diffusion MRI Protocols between MR Systems (Traditional Poster, Abstract #1665) In: Proceedings of the 27th Annual Meeting of ISMRM, Paris, France 2018 Hurley SA, Rajala AZ, Filla CN, Birn RM, Block WF, Alexander AL, Converse AK, Zammit MD, Christian BT, McMillan AB, Populin LC. PET/MR Platform for Neuroscience in Awake Behaving Non-Human Primates (Traditional Poster) In: ISMRM-SNMMI Workshop on PET/MRI, Chicago, IL, USA 2017 Hurley SA, Alexander AL. Assessment of mcDESPOT Precision Using Constrained Estimation (Traditional Poster, Abstract #3144) In: Proceedings of the 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014 Hurley SA, Mossahebi P, Johnson KM, Samsonov AA. Simultaneous Mapping of B1 and Flip Angle by Combined Bloch-Siegert, Actual Flip-angle Imaging (BS-AFI) (Oral Presentation, Abstract #0050) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Victoria, Australia 2012 Hurley SA, Tromp DPM, Emborg ME, Ohshima-Hosoyama S, Brady M, Raghavan R, Kubota K, Alexander AL. MR Monitoring of Non Contrast-enhanced brain infusion with MRI T1 Mapping (Traditional Poster, Abstract #0048) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Victoria, Australia 2012 *Interventional Study Group Top 10 Poster Award. Hurley SA, Yarnykh VL, Samsonov AA. Spoiling properties of the VAFI method for fast simultaneous T1 and B1 mapping from actual flip-angle imaging (AFI) and variable flip-angle (VFA) data. (E-Poster, Abstract #4488) In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2011 Hurley SA*, Mossahebi P*, Samsonov AA, Alexander AL, Deoni SC, Fisher R, Duncan ID, Field AS. Multicomponent Relaxometry (mcDESPOT) in the Shaking Pup Model of Dysmyelination. (E-Poster, Abstract #0088) In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden 2010 Hurley SA, Samsonov AA. Accurate and Efficient Mapping of Flip Angle and T1 using Simultaneous Actual Flip Angle - Variable Flip Angle Imaging. (E-Poster, Abstract #4480) In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, HI, USA 2009 *Equal contribution among starred authors. Conference Proceedings - Contributing Author Wille CM, Hurley S, Kijowski R, Heiderscheit BC. Region of Interest Definition for Diffusion Tensor Imaging following Acute Hamstring Strain Injuries. Scientific Presentation (ePoster). Radiological Society of North America Annual Meeting, Dec 2020. Block WF, Birn R, Olsen M, Hurley SA, Brodsky EK, Rajala A, Filla C, McMillan A, Alexander AL, Jenison RL, Populin LC. MR-Guided Pharmacological Intervention: Creating Causal Capabilities for fMRI (Oral Presentation, Abstract #1054) In: 27th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2019 Birn RM, Hurley SA, Rajala AZ, Filla CN, Patrick AM, Gwozdz DJ, Block WF, Alexander AL, Converse AK, Jenison RL, Christian BT, McMillan AB, Populin LC. PET/MR Platform for Neuroscience in Awake Behaving Non-Human Primates (Traditional Poster, Abstract #3030) In: 26th Annual Meeting of ISMRM, Paris, France 2018 Clarke C, Kitzbichler M, Barker G, Correia M, Dowell N, Hurley SA, Mclean J, Wood TC, NIMA Consortium, Cercignani M, Bullmore E, Harrison N. BIOmarkers of DEPression (BIODEP) study: Raised peripheral inflammation associated with changes in striatal microstructure (E-Poster, Abstract #3661) In: 26th Annual Meeting of ISMRM, Paris, France 2018 Feng Q, Hurley SA, Pallebage-Gamarallage M, Ansorge O, Turner M, Menke R, Foxley S, Miller KL. Correction of Fixation Effects in Post-Mortem T2 Measurements Using a Kinetic Tensor Model (E-Poster, Abstract #3728) In: 25th Annual Meeting of ISMRM, Honolulu, HI, USA, 2017 Metere R, Hurley SA, Pampel A, Miller KL, Möller H. A Singular Value Decomposition Approach to Quantitative Magnetization Transfer (Traditional Poster, Abstract #1969) In: 25th Annual Meeting of ISMRM, Honolulu, HI, USA, 2017 Wood TC, Simmons C, Torres J, Dell'Acqua F, Vernon A, Hurley SA, Williams S, Cash D. Whole-Brain Ex-Vivo Imaging of Demyelination in the Cuprizone Mouse with McDESPOT and DTI (Traditional Poster, Abstract #1317) In: 24th Annual Meeting of ISMRM, Republic of Singapore, 2016 Alexander D, Ghosh A, Hurley SA, Sotiropoulos S. Image Quality Transfer Benefits Tractography of Low-Resolution Data (Oral, Abstract #0120) In: 24th Annual Meeting of ISMRM, Republic of Singapore, 2016 Bouyagoub S, Dowell N, Hurley SA, Wood TC, Cercignani M. Overestimation of CSF Fraction in NODDI: Possible Correction Techniques and the Effect on Neurite Density and Orientation Dispersion Measures (E-Poster, Abstract #0007) In: 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014 Wood TC, Hurley SA, Barker GJ, Williams SCR. An SSFP Signal Equation with Finite RF Pulses and Exchanging Water Pools (Traditional Poster, Abstract #1464) In: 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014 Chaudhary R, Liu F, Sritanyaratana N, Kaiser JM, Hurley SA, Block WF, Kijowski R. Sensitivity of Multicomponent Driven Equilibrium Single Observation of T1 and T2 (mcDESPOT) to Magic Angle Effects in Bovine Articular Cartilage at 3.0T (Oral Presentation, Abstract #0149) In: Proceedings of the 22nd Annual Meeting of ISMRM, Milan, Lombardy, Italy 2014 McLellan GL, Hurley SA, Mossahebi P, Ellinwood NM, Field AS. Quantitative MRI-derived optic nerve microstructural features in a feline glaucoma model. ARVO-ISIE Imaging Conference, Orlando, Florida, May 2014 Grabow BP, Kubota K, Raghavan R, Brady M, Ross C, Hurley SA, Brodsky EK. Real-Time Monitoring For Systematic Investigation Of Catheter Design And Infusion Protocol Effect On CED Performance. In: 17th International Congress Of Parkinson's Disease And Movement Disorders, Volume 28, Sydney, Australia, 16-20 June 2013. Grabow BP, Raghavan R, Brady M, Kubota K, Ross C, Hurley SA, Brodsky EK, Raschke J, Alexander AL, Block WF. Real-Time Monitoring For Systematic Investigation Of Catheter Design And Infusion Protocol Effect On CED Performance. In: 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013. Kecskemeti S, Adluru N, Hurley S, Alexander AL. Multi-spectral T1 Weighted Imaging and T1 Quantification using 3D Radial k-space Trajectory (Traditional Poster, Abstract #0452) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013 Liu F, Chaudhary R, Hurley SA, Samsonov AA, Alexander AL, Deoni SCL, Block WF, Kijowski R. Multi-Component T2 Analysis of Cartilage Degradation Model Using mcDESPOT at 3.0T (Traditional Poster, Abstract #1655) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013 Liu F, Hurley SA, Samsonov AA, Alexander AL, Deoni SCL, Block WF, Kijowski R. Multi-Component T2 Analysis of Articular Cartilage with Synovial Fluid Partial Volume Correction using mcDESPOT at 3.0T (Oral Presentation, Abstract #0636) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013 Wood TC, Hurley SA, Vernon A, Williams SCR. High Resolution Imaging of Rodent Brains at 7T. (Traditional Poster, Abstract #2465) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013 Ollinger JM, Hurley SA, Alexander AL, Riedy G. A Constrained Estimator of Myelin Water Fraction from Steady-State Data (Traditional Poster, Abstract #4210) In: Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013 Venkateswaran M, Hurley SA, Samsonov AA, Wang P, Unal O, Kurpad KN. An Accurate Electromagnetic Field Model for Optimization and Selection of Intravascular Multimode Coil Geometry (Traditional Poster, Abstract #4317) In: 21st Annual Meeting of ISMRM, Salt Lake City, UT, USA 2013 Hutchinson, E., Elangbam, N., Hurley, SA., Alexander, A., Rutecki, P., Sutula, T. Quantitative Manganese-enhanced MRI detection of differences between kindling-susceptible and kindling-resistant strains of rats. In: Society for Neuroscience, New Orleans, LA, USA October 2012. Grabow BP, Block WF, Hurley SA, Sillay KA, Brodsky EK. Accessible Animal Models for Interventional Neurosurgery Training and Research (Poster Presentation, Abstract #112) In: 9th International Interventional MRI Symposium, Boston, MA, USA 2012. Venkateswaran M, Kurpad KN, Hurley SA, Wang P, Unal O. Endovascular Multimode Coil Characterization Using B1 Field Mapping (Poster Presentation, Abstract #087) In: 9th International Interventional MRI Symposium, Boston, MA, USA 2012. Liu F, Hurley
SA, Sritanyaratana N, Block WF, Kijowski R. Multi-Exponential T2
Mapping of Human Patellar Cartilage Using mcDESPOT (Oral Presentation,
Abstract #4365) In: Proceedings of the 20th Annual Meeting of ISMRM, Melbourne,
Victoria, Australia 2012 Brodsky EK, Block WF, Alexander AL, Grabow BP, Hurley SA, Ross CD, Sillay KA. Intraoperative Targeting, Trajectory Planning, Device Insertion and Infusion Monitoring with Real-Time MRI (Oral Presentation) In: International MRA Club 23rd Annual Conference, Bannf, Alberta, Canada. September 2011. Velikina JV, Hurley SA, Alexander AL, Samsonov AA. Accelerating Multi-Component Relaxometry in Steady State with an Application of Constrained Reconstruction in Parametric Dimension. (Abstract #2740) In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2011 Sritanyaratana N, Samsonov AA, Hurley SA, Johnson KM, Mossahebi P, Block WF, Kijowski R.Quantitative Magnetization Transfer of Entire Human Patellofemoral Joint in 30 Minutes. (E-Poster, Abstract #4318) In: Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Quebec, Canada 2011 Hosseinbor AP, Duncan ID, Alexander AL, Samsonov AA, Wu Y-C, Hurley SA, Fisher RA, Field AS. Hybrid Diffusion Imaging in a Spinal Cord Model of Dysmyelination. (Traditional Poster, Abstract #2135) In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, Sweden 2010 Lopas LA, Moirano JM, Kurpad KN, Hurley SA, Converse AK. Design, Construction, and Testing of RF Coil and Animal Body Holder for Simultaneous PET/MRI Imaging of Rat Brain. (Traditional Poster) BrainPET (2009) Conference Attendance Annual Meeting of ISMRM
Other
Projects Quantitative MRI Analysis Package - Samsonov AA, Mossahebi P, Hurley SA. www.qmri.net/qmap A collection of quantitative MRI analysis software written in Matlab. This includes mathematical models of MRI sequences for measurement of quantitative parameters including T1, T2, bound pool fraction, and exchange rates. ISMRM Challenge - Organizing Committee Member. www.ismrm.org/challenge ISMRM Challenge is an initiative to foster impactful innovation in MRI applications and methodology through a series of year-around competitions. It is based on the premise of individuals and teams submitting reconstruction codes, which are tested and scored against a series of test cases in an automated fashion.
Professional Associations
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